Kirkland Signature Timed Release B100 Complex is a one-per-day formula providing the eight essential B vitamins needed for the maintenance of good health (1), with choline and inositol for comprehensive B vitamin coverage. (2,3) B vitamins work together as coenzymes in many of the body’s biochemical processes. (4) Coenzymes, compounds necessary for enzyme functioning, participate in many biochemical reactions involving energy release and other types of reactions. (4) Because the body does not store them, B vitamins need to be consumed in sufficient quantities daily to support the maintainance good health. (1) Methylcobalamin is the biochemically active form of vitamin B12 and is one of the preferred supplemental forms. (5) It helps the immune system’s normal function (6) and works with niacin, riboflavin, thiamine, and pantothenic acid to support energy production and help maintain the body’s ability to metabolize nutrients. (7,8) Vitamin B12, vitamin B6, and folic acid contribute to forming red blood cells, while vitamin B2 (riboflavin) helps maintain normal red blood cells and normal metabolism of iron. (9–11) Biotin helps maintain healthy hair, nail, mucous membranes, and skin (12–14) by contributing to keratin production for nails and hair, and is a factor in the biochemical synthesis of fatty acids. (15,16) Features and Benefits: • Features the premium form of B12 – Methylcobalamin • Contains 500 mcg of B12 per tablet • Provides 100 mg of choline (a form of Choline Bitartrate) per tablet • One-per-day formula • No Gluten • No Lactose • Non-GMO • Free of artificial flavours, colours, and preservatives • No Yeast, Sodium, Hydrogenated Oils, or Gelatin • NPN: 80107104 Includes: • 300 Timed-release tablets Ingredients (each tablet): • Vitamin B12 (Methylcobalamin): 500 mcg • Biotin: 100 mcg • Vitamin B5 (Pantothenic Acid) (calcium d-pantothenate): 100 mg • Choline (Choline Bitartrate): 100 mg • Inositol: 100 mg • Vitamin B3 (Niacinamide): 100 mg • Vitamin B6 (Pyridoxine Hydrochloride): 100 mg • Vitamin B2 (Riboflavin): 100 mg • Vitamin B1 (Thiamine Mononitrate): 100 mg • Vitamin B9 (Folic Acid / Folate): 1000 mcg Non-medicinal ingredients: • Microcrystalline cellulose, dibasic calcium phosphate dihydrate, hydroxypropyl methylcellulose, coating (carbohydrate gum, vegetable glycerin [palm and palm kernel oils [RSPO certified]]), vegetable grade magnesium stearate (lubricant). Recommended dosage (Adults): • 1 Tablet daily or as directed by a physician. Servings: • 300 Days Warnings: • Keep out of reach of children. Storage: • For product freshness, protect from heat and humidity. References: 1. Shils ME, Shike M. Modern nutrition in health and disease. 10th ed. Philadelphia: Lippincott Williams and Wilkins; 2006. p. 426-506. 2. Wiedeman AM, Barr SI, Green TJ, et al. Dietary choline intake: Current state of knowledge across the life cycle. Nutrients. 2018; 10(10):1513. 3. Kuksis A, Mookerjea S. Inositol. Nutr Rev. 1978; 36(8):233-8. 4. Freeland-Graves JH, Bavik C. Coenzymes. In: Encyclopedia of food sciences and nutrition. 2nd edition. Edited by Cabarello B. New York: Academic Press, 2003. p. 1475-81. 5. Paul C, Brady DM. Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms. Integr Med (Encinitas). 2017; 16:42-9. 6. Gombart AF, Pierre A, Maggini S. A review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients. 2020; 12(1):236. 7. Tardy AL, Pouteau E, Marquez D, et al. Vitamins and minerals for energy, fatigue and cognition: A narrative review of the biochemical and clinical evidence. Nutrients. 2020; 12(1):228. 8. Depeint F, Bruce WR, Shangari N, et al. Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact. 2006; 163(1-2):94. 9. Koury MJ, Ponka P. New insights into erythropoiesis: The roles of folate, vitamin B12, and iron. Annu Rev Nutr. 2004; 24:105-31. 10. Bickers JN, Brown CI, Sprague CC, et al. Pyridoxine responsive anemia. Blood. 1962; 19(3):304-12. 11. Powers HJ, Hill MH, Mushtaq S, et al. Correcting a marginal riboflavin deficiency improves hematologic status in young women in the United Kingdom (RIBOFEM). Am J Clin Nutr. 2011; 93(6):1274-84. 12. Hochman LG, Scher RK, Meyerson MS. Brittle nails: Response to daily biotin supplementation. Cutis. 1993; 51(4):303-5. 13. Patel DB, Swink SM, Castelo-Soccio L. A review of the use of biotin for hair loss. Skin Appendage Disord. 2017; 3(3):166-9. 14. Keipert JA. Oral use of biotin in seborrhoeic dermatitis of infancy: A controlled trial. Med J Aust. 1976; 1(16):584-5. 15. Fletcher K, Myant N. Biotin in the synthesis of fatty acid and cholesterol by mammalian liver. Nature. 1960; 188:585. 16. Zempleni J, Wijeratne SS, Hassan YI. Biotin. Biofactors. 2009; 35:36-46.